Selected Publications
Qin K., Lan X., Huang P., Saari M.S., Khandros E., Keller C.A., Giardine B., Abdulmalik O., Shi J., Hardison R.C., and Blobel G.A. (2023) Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood, epub ahead of print.
Vermunt M.W., Luan J., Zhang Z., Huang A., Thrasher A.J., Zhang S., Vemulamada P., Brilleman M., Lee K., Giardine B., Keller C.A., Hardison R.C., and Blobel G.A. (2022) Gene silencing dynamics are modulated by transiently active regulatory elements. Molecular Cell 83:715-730 (Featured Article and Preview in Molecular Cell)
Luan J, Vermunt MW, Syrett CM, Coté A, Tome JM, Zhang H, Huang A, Luppino JM, Keller CA, Giardine BM, Zhang S, Dunagin MC, Zhang Z, Joyce EF, Lis JT, Raj A, Hardison RC, Blobel GA. CTCF blocks antisense transcription at divergent promoters. Nat Struct Mol Biol. 29:1136-1144, 2022
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nat Genet. 54:1417, 2022
Adema V, Ma F, Kanagal-Shamanna R, Thongon N, Montalban-Bravo G, Yang H, Peslak SA, Wang F, Acha P, Sole F, Lockyer P, Cassari M, Maciejewski JP, Visconte V, Gañán-Gómez I, Song Y, Bueso-Ramos C, Pellegrini M, Tan TM, Bejar R, Carew JS, Halene S, Santini V, Al-Atrash G, Clise-Dwyer K, Garcia-Manero G, Blobel GA, Colla S. Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts. Blood Cancer Discov 3:554, 2022
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallières M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA. Identification of RBM12 as a novel regulator of fetal hemoglobin silencing in adult erythroid cells. Blood Adv 6:5956, 2022
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet 54:874, 2022
Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA.: CTCF and transcription influence chromatin structure re-configuration after mitosis. Nat Comm. 12: 5157, Aug 2021.
Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA.: Distinct properties and functions of CTCF revealed by a rapidly inducible degron system. Cell Rep 34: 108783, Feb 2021.
Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA.: ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol Cell 81: 239-254, Jan 2021.
Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, Blobel GA.: Alteration of genome folding via contact domain boundary insertion. Nat Genet 52: 1076-1087, Oct 2020.
Zhang Haoyue, Emerson Daniel J, Gilgenast Thomas G, Titus Katelyn R, Lan Yemin, Huang Peng, Zhang Di, Wang Hongxin, Keller Cheryl A, Giardine Belinda, Hardison Ross C, Phillips-Cremins Jennifer E, Blobel Gerd A: Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature 576: 158-162, 12 2019.
Behera Vivek, Stonestrom Aaron J, Hamagami Nicole, Hsiung Chris C, Keller Cheryl A, Giardine Belinda, Sidoli Simone, Yuan Zuo-Fei, Bhanu Natarajan V, Werner Michael T, Wang Hongxin, Garcia Benjamin A, Hardison Ross C, Blobel Gerd A: Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Cell Reports 27: 400-415.e5, Apr 2019.
Bartman CR, Hamagami N, Keller CA, Giardine B, Hardison RC, Blobel GA, Raj A: Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation. Molecular Cell 2019.
Behera V, Evans P, Face CJ, Hamagami N, Sankaranarayanan L, Keller CA, Giardine B, Tan K, Hardison RC, Shi J, Blobel GA: Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility. Nature Communications 2018.
Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, and Blobel GA: Domain-focused CRISPR-screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science 2018.